Why the study?
Does theophylline alter the effects of phenylephrine on cardiac relaxation and contraction in isolated rabbit left atria?
Population
Driven isolated left atrium of the rabbit
Comparison
Theophylline and phenylephrine vs Isoprenaline, histamine, calcium, and baseline…
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for calcium-dependent separation of relaxation and contraction in cardiac tissue.
Does theophylline alter the effects of phenylephrine on cardiac relaxation and contraction in isolated rabbit left atria?
Theophylline separates the effects of phenylephrine on cardiac relaxation (beta-adrenoceptor mediated) and contraction (alpha-adrenoceptor mediated) in isolated rabbit atria.
B. G. Benfey (1977) studied this question.
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