What is the clinical evidence from this study?

Study design: Observational. Population: Cardiac allograft rejection (n=169). Intervention: Expression of CXCR3 and IP-10 vs. Normal biopsies. Primary outcome: Histopathological diagnosis of acute rejection (OR 19.43, p=0.01).

What question did this study set out to answer?

To determine the expression and potential role of chemokine receptors and their ligands, particularly CXCR3 and IP-10, during human cardiac allograft rejection.

August 10, 2026Circulation

Expression of the Chemokine Receptor CXCR3 and Its Ligand IP-10 During Human Cardiac Allograft Rejection

Q: What are the key findings of this study?

Expression of the chemokine receptor CXCR3 and its ligand IP-10 in endomyocardial biopsies strongly correlates with acute cardiac allograft rejection (OR 4.05, P<0.001 and OR 19.43, P=0.01).

Q: What does this research mean for the field?

Expression of the chemokine receptor CXCR3 and its ligand IP-10 in endomyocardial tissue is strongly associated with acute cardiac allograft rejection. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Biopsy expression of IP-10 is linked to a ~19-fold higher risk of acute allograft rejection.

OR 19.43
P=0.01
n=169

Key Points

To determine the expression and potential role of chemokine receptors and their ligands, particularly CXCR3 and IP-10, during human cardiac allograft rejection.
Analyzed 169 sequential human endomyocardial biopsies using immunocytochemistry to evaluate CD3(+) T-cell infiltration and expression of chemokine receptors CCR1, CCR3, CCR5, and CXCR3.
Conducted RT-PCR on 35 additional biopsies to evaluate chemokine expression, including eotaxin, IP-10, lymphotactin, MCP-1, Mig, RANTES, and SDF-1.
Followed 7 patients longitudinally for 1 year with intravascular ultrasound to monitor the development of intimal thickening.
CXCR3 expression was temporally and spatially linked with CD3(+) T-cell infiltration and significantly correlated with acute rejection histopathology (OR, 11.73 and 4.05, respectively; P<0.001).
The CXCR3 ligand IP-10 was rarely detected in normal tissue but was strongly induced in acute rejection biopsies (OR, 19.43; P=0.01).

Study Design

Type

Observational (n=169)

Structured PICO

Population

169 sequential human endomyocardial biopsies from cardiac allograft recipients analyzed for chemokine receptor expression and acute rejection.

Comparator

Normal (non-rejecting) endomyocardial biopsies

Outcome

Expression of chemokine receptors (CCR1, CCR3, CCR5, CXCR3) and ligands (including IP-10) and their correlation with CD3+ T-cell infiltration and histopathological diagnosis of acute rejectionsurrogate

Main Result

Odds Ratio: 19.43

p-value: p=0.01

Discussion

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Implication

The presence of CXCR3+ T cells and the ligand IP-10 in endomyocardial biopsies is strongly associated with acute cardiac allograft rejection, identifying a potential therapeutic target.

Cite This Study

Melter et al. (2001) conducted an observational in Cardiac allograft rejection (n=169). Expression of CXCR3 and IP-10 vs. Normal biopsies was evaluated on Histopathological diagnosis of acute rejection (OR 19.43, p=0.01). Expression of the chemokine receptor CXCR3 and its ligand IP-10 in endomyocardial biopsies strongly correlates with acute cardiac allograft rejection (OR 4.05, P<0.001 and OR 19.43, P=0.01).

synapsesocial.com/papers/6a7a40475f4b5a3f9cb2843d https://doi.org/10.1161/hc4601.098010

Topics

Heart transplantation

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Implication

The presence of CXCR3+ T cells and the ligand IP-10 in endomyocardial biopsies is strongly associated with acute cardiac allograft rejection, identifying a potential therapeutic target.

Expression of the Chemokine Receptor CXCR3 and Its Ligand IP-10 During Human Cardiac Allograft Rejection

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Expression of the Chemokine Receptor CXCR3 and Its Ligand IP-10 During Human Cardiac Allograft Rejection

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider