Key result
In a rat carotid artery balloon injury model, adventitial fibroblasts activated, proliferated, and migrated to the media and intima by day 7, actively participating in revascularization.
This study provides direct evidence that adventitial fibroblasts activate and migrate to the media and intima following vascular injury, contributing to vascular remodeling.
Animal data on adventitial fibroblast migration should not guide therapy; leaves open their role in human vascular remodeling.
The rat carotid artery balloon injury model was used to prove the activation and migration of adventitial fibroblasts. We found that at day 7 after injury, adventitial fibroblasts proliferated, transformed into myofibroblasts under transmission electron microscopy in the model group. Simultaneously, we proved that the adventitial cells migrated to the media and intima on seventh day after injury by directly labeled the adventitial cells by the in vivo gene transfer technique. Moreover, we captured the precise moment when the adventitial fibroblasts migrated from the adventitia to the media through the external elastic plate under transmission electron microscope. This study provides direct evidences that adventitial fibroblasts activate and migrate to the media and intima, then actively take part in revascularization. Anat Rec, 301:1216-1223, 2018.
No takes yet. Share an insight, caveat, or question.
Han et al. (2018) studied Vascular remodeling. Balloon injury was evaluated on Activation and migration of adventitial fibroblasts. In a rat carotid artery balloon injury model, adventitial fibroblasts activated, proliferated, and migrated to the media and intima by day 7, actively participating in revascularization.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: