May 27, 2003Cardiovascular Research

Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries

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Population

Male Sprague-Dawley rats

Comparison

In vivo gene transfer of an adenoviral vector… vs Uninjured arteries and untransfected right…

Design

Preclinical

Follow-up

Up to 14 days after injury

Authors

RSRichard SiowKing's College - North Carolina

Discussion

Member takes

Implication

Hypothesis-generating for adventitial targeting in restenosis; leaves open human relevance and therapeutic translation.

Structured PICO

Population

Male Sprague-Dawley rats

Intervention

In vivo gene transfer of an adenoviral vector expressing nuclear targeted beta-galactosidase (AdLacZ) applied to the perivascular surface of left carotid arteries, followed by balloon catheter mediated vascular injury 4 days later

Comparator

Uninjured arteries and untransfected right carotid arteries

Outcome

Migration of LacZ positive cells into the medial layer and neointima, and expression of smooth muscle alpha-actinsurrogate

This study provides direct evidence that adventitial fibroblasts migrate and differentiate into myofibroblasts, contributing to neointima formation after vascular balloon injury.

Cite This Study

Richard Siow (2003) studied this question.

synapsesocial.com/papers/6a951863aa92d0f3572c9399 https://doi.org/10.1016/s0008-6363(03)00292-x

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Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider