October 1, 1994CirculationOpen Access

Cardiac myocyte function and left ventricular strains after brief ischemia and reperfusion in rabbits.

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Population

17 anesthetized rabbits

Comparison

15 minutes of regional ischemia followed by… vs Pre-ischemia control values and cardiac myocytes…

Design

Preclinical

Follow-up

1 to 6 hours after reperfusion

Authors

WLWilbur Y.W. LewVeterans Medical Research Foundation of San Diego YNYasuhiko NishikawaNagasaki University HSHsing-Hui SuUniversity of Cambridge

Discussion

Member takes

Implication

May explain load-independent stunning after brief ischemia; hypothesis-generating for human mechanisms and therapies.

Structured PICO

Population

17 anesthetized rabbits (7 for in vivo strain measurement, 5 for postischemic myocyte isolation, 5 normal controls for myocyte isolation)

Intervention

15 minutes of regional ischemia followed by reperfusion

Comparator

Pre-ischemia control values (in vivo) and cardiac myocytes isolated from normal rabbits (in vitro)

Outcome

In vivo regional two-dimensional finite strains and in vitro unloaded cell shorteningsurrogate

Brief ischemia and reperfusion induce intrinsic impairments in myocyte contractility that are independent of external loading conditions.

Cite This Study

Lew et al. (1994) studied this question.

synapsesocial.com/papers/6a7a489fb2ad017e4032228a https://doi.org/10.1161/01.cir.90.4.1942

Topics

Women and heart disease

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Cardiac myocyte function and left ventricular strains after brief ischemia and reperfusion in rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac myocyte function and left ventricular strains after brief ischemia and reperfusion in rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider