Key result
Aqueous, ethanol, and aqueous ethanol extracts of Aerva lanata (200 mg/kg) demonstrated significant cardioprotective activity against doxorubicin-induced cardiomyopathy in rats (P<0.05).
Why the study?
Do aqueous, ethanol, and aqueous ethanol extracts of Aerva lanata prevent doxorubicin-induced cardiomyopathy in Wistar rats?
Population
Wistar rats with doxorubicin-induced cardiomyopathy
Comparison
Aqueous, ethanol, and aqueous ethanol extracts… vs Standard allopathic drug aspirin
Design
Preclinical
Follow-up
28 days
Authors
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Hypothesis-generating for Aerva lanata in doxorubicin cardiotoxicity; human trials needed before clinical consideration.
Do aqueous, ethanol, and aqueous ethanol extracts of Aerva lanata prevent doxorubicin-induced cardiomyopathy in Wistar rats?
p-value: p=<0.05
Aerva lanata extracts showed significant cardioprotective effects against doxorubicin-induced cardiomyopathy in rats, providing scientific support for its traditional use.
Ragavendran et al. (2012) studied Doxorubicin induced cardiomyopathy. Aqueous, ethanol and aqueous ethanol extract of Aerva lanata vs. Aspirin was evaluated on Cardioprotective activity (enzymatic/non-enzymatic antioxidants, lipid peroxidation, membrane bound enzymes, cardiac biomarkers, lipid profiles, histopathology) (p=<0.05). Aqueous, ethanol, and aqueous ethanol extracts of Aerva lanata (200 mg/kg) demonstrated significant cardioprotective activity against doxorubicin-induced cardiomyopathy in rats (P<0.05).