What question did this study set out to answer?

To determine the prognostic value of p53 and c-erbB-2 protein overexpression and evaluate their relationship with tumor cell proliferation in patients with axillary node-negative breast cancer.

July 15, 1992JNCI Journal of the National Cancer Institute

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

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To determine the prognostic value of p53 and c-erbB-2 protein overexpression and evaluate their relationship with tumor cell proliferation in patients with axillary node-negative breast cancer.
Randomly selected 289 axillary node-negative breast cancer cases from a population-based cohort who received no adjuvant chemotherapy or endocrine therapy.
Evaluated p53 and c-erbB-2 overexpression in archival paraffin-embedded tumor samples using immunohistochemistry.
Measured cell proliferation rates as S-phase fractions using DNA flow cytometry and analyzed outcomes with multivariate Cox regression.
High-level p53 overexpression occurred in 41 of 289 tumors and correlated with high histologic grade, negative estrogen receptor status, and highest S-phase fractions when co-occurring with c-erbB-2 (P < .0001).
Eight-year survival was 56% in patients with p53 protein overexpression compared with 81% without overexpression (relative risk: 3.7; P < .0001).
In multivariate Cox regression analysis including S-phase fraction, only tumor size and S-phase fraction remained independent predictors of survival.

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Implication

Cohort study reveals p53 overexpression links to rapid proliferation and lower survival in node-negative breast cancer, indicating its prognostic impact depends on cell division rates.

Cite This Study

Isola et al. (1992) studied this question.

synapsesocial.com/papers/6a7a501fa51ded8e7b32a9d8 https://doi.org/10.1093/jnci/84.14.1109

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Implication

Cohort study reveals p53 overexpression links to rapid proliferation and lower survival in node-negative breast cancer, indicating its prognostic impact depends on cell division rates.

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

Key Points

Discussion

Implication

Cite This Study

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

Key Points

Discussion

Implication

Cite This Study

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