What question did this study set out to answer?

To determine the relationship between mutant p53 protein expression, tumor cell proliferation rate, and clinical outcomes in patients with node-negative breast cancer.

February 3, 1993JNCI Journal of the National Cancer Institute

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

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Authors

DAD. Craig AllredUniversity of Vermont GCGary M. ClarkDana-Farber Brigham Cancer Center RERichard ElledgeThe University of Texas Health Science Center at San Antonio

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Implication

Cohort study reveals mutant p53 expression and high proliferation independently predict recurrence and mortality in node-negative breast cancer, highlighting their value for risk stratification.

Key Points

To determine the relationship between mutant p53 protein expression, tumor cell proliferation rate, and clinical outcomes in patients with node-negative breast cancer.
Evaluated mutant p53 expression via frozen-section immunohistochemistry (IHC scores: 0, 2–8) and tumor proliferation (%S phase) via flow cytometry in N=700 node-negative breast cancer patients with a median follow-up of 54 months.
Performed univariate cutpoint analyses and multivariate modeling to correlate p53 levels and %S phase with disease-free survival and overall survival.
Tumors with positive p53 expression (52%, 362/700) exhibited significantly higher proliferation rates (median %S phase: 7.1%) than negative tumors (4.1%, P = .0001).
Five-year disease-free survival was 80% in negative (n=388), 72% in low-positive (n=263), and 58% in high-positive (n=99) tumors (P <= .05 for all pairwise comparisons); 5-year overall survival was 88% vs 84% vs 74% (P = .003 for negative vs high-positive).
Multivariate analysis confirmed that p53 protein expression (P = .008) and high %S phase (P = .01) were independent prognostic factors for reduced disease-free survival.

Cite This Study

Allred et al. (1993) studied this question.

synapsesocial.com/papers/6a1a1dd73f3ec013f0df80e1 https://doi.org/10.1093/jnci/85.3.200

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Implication

Cohort study reveals mutant p53 expression and high proliferation independently predict recurrence and mortality in node-negative breast cancer, highlighting their value for risk stratification.

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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