Key result
High normal blood pressure was associated with significantly increased arterial stiffness, including higher pulse wave velocity (7.31 vs 6.34 m/s) and reduced flow-mediated dilation compared to optimal blood pressure.
Why the study?
The study was conducted to establish the changes in function and structure of large arteries in individuals with high normal arterial pressure.
Are there structural and functional vascular changes in individuals with high normal arterial pressure compared to those with optimal arterial pressure?
Cross-Sectional (n=126)
No
Are there structural and functional vascular changes in individuals with high normal arterial pressure compared to those with optimal arterial pressure?
Absolute Event Rate: 7.31% vs 6.34%
p-value: p=<0.05
Individuals with high normal arterial pressure exhibit increased arterial stiffness compared to those with optimal blood pressure, despite low overall cardiovascular risk.
Early arterial changes in HNAP warrant monitoring; leaves open whether they predict events or merit intervention.
The PURPUSE of the present study is changes in function and structure of large arteries in individuals with High Normal Arterial Pressure (HNAP) to be established. MATERIAL and METHODS: Structural and functional changes in the large arteries were investigated in 80 individuals with HNAP and in 45 with optimal arterial pressure (OAP). In terms of arterial stiffness, pulse wave velocity (PWV), augmentation index (AI), central aortic pressure (CAP), pulse pressure (PP) were followed up in HNAP group. Intima media thickness (IMT), flow-induced vasodilatation (FMD), ankle-brachial index (ABI) were also studied. RESULTS: Significantly increased values of pulse wave velocity, augmentation index, central aortic pressure, pulse pressure are reported in the HNAP group. In terms of IMT and ABI, being in the reference interval, there is no significant difference between HNAP and OAP groups. The calculated cardiovascular risk (CVR) in both groups is low. CONCLUSION: Significantly higher values of pulse wave velocity, augmentation index, central aortic pressure and pulse pressure in the HNAP group are reported.
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P Nikolov (2020) conducted a cross-sectional in High Normal Arterial Pressure (n=126). High Normal Blood Pressure vs. Optimal Blood Pressure was evaluated on Pulse wave velocity (PWV) (p=<0.05). High normal blood pressure was associated with significantly increased arterial stiffness, including higher pulse wave velocity (7.31 vs 6.34 m/s) and reduced flow-mediated dilation compared to optimal blood pressure.
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