Key result
Radiofrequency catheter ablation of the hypertrophied septum reduced the mean LVOT gradient from 81 mm Hg at baseline to 42.8 mm Hg at 12 months (p=0.05) in patients with HOCM.
Why the study?
Does radiofrequency catheter ablation reduce LVOT gradient and improve symptoms in patients with symptomatic HOCM and unfavorable anatomy for alcohol septal ablation?
Observational (n=7)
Does radiofrequency catheter ablation reduce LVOT gradient and improve symptoms in patients with symptomatic HOCM and unfavorable anatomy for alcohol septal ablation?
Absolute Event Rate: 42.8% vs 81%
p-value: p=0.05
Radiofrequency catheter ablation of the hypertrophied septum provides sustained reduction in LVOT gradient and symptomatic improvement in HOCM patients with unfavorable anatomy for alcohol septal ablation.
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RFCA may be feasible in select HOCM patients; leaves open need for randomized trials before wider adoption.
Shelke et al. (2016) conducted an observational in Symptomatic hypertrophic obstructive cardiomyopathy (HOCM) (n=7). Radiofrequency catheter ablation (RFCA) vs. Baseline was evaluated on Mean LVOT gradient by Doppler echocardiography at 12 months (p=0.05). Radiofrequency catheter ablation of the hypertrophied septum reduced the mean LVOT gradient from 81 mm Hg at baseline to 42.8 mm Hg at 12 months (p=0.05) in patients with HOCM.
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