What question did this study set out to answer?

To determine whether naturally occurring regulatory T cells can directly suppress autoantibody-producing B cells in systemic lupus erythematosus without relying on T helper cell intermediaries.

July 2, 2009The Journal of ImmunologyOpen Access

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

View Full Paper

Ask AI

Bookmark

To determine whether naturally occurring regulatory T cells can directly suppress autoantibody-producing B cells in systemic lupus erythematosus without relying on T helper cell intermediaries.
Assessed the inhibitory impact of natural CD4(+)CD25(+)Foxp3(+) regulatory T cells on B cell function using both in vitro and in vivo systemic lupus erythematosus models.
Evaluated contact-dependent suppression mechanisms on autoantibody-producing B cells, focusing on subsets that expand during active disease.
Natural regulatory T cells inhibited autoantibody-producing B cells directly through cell-contact-mediated mechanisms both in vitro and in vivo.
Direct suppression targeted autoreactive B cell populations that undergo numerical expansion during active systemic lupus erythematosus.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical investigation reveals direct suppression of autoreactive B cells by regulatory T cells in systemic lupus erythematosus, highlighting an innate brake on humoral autoimmunity.

Cite This Study

Iikuni et al. (2009) studied this question.

synapsesocial.com/papers/6a7a58b535e7b6bcc689191d https://doi.org/10.4049/jimmunol.0901163

View Full Paper

Ask AI

Bookmark

Implication

Preclinical investigation reveals direct suppression of autoreactive B cells by regulatory T cells in systemic lupus erythematosus, highlighting an innate brake on humoral autoimmunity.

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

Key Points

Discussion

Implication

Cite This Study

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider