Why the study?
Does dopamine treatment of postischemic contractile dysfunction induce cardiomyocyte apoptosis in isolated rabbit hearts?
Population
Isolated perfused rabbit hearts subjected to 45 minutes of normothermic ischemia with cardioplegic arrest
Comparison
Reperfusion for 120 minutes with perfusate… vs Reperfusion with unmodified perfusate (control)
Design
Preclinical
Follow-up
120 minutes
Authors
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May caution dopamine use in postischemic dysfunction; hypothesis-generating for apoptosis relevance in clinical reperfusion.
Does dopamine treatment of postischemic contractile dysfunction induce cardiomyocyte apoptosis in isolated rabbit hearts?
In a rabbit heart model, postischemic dopamine treatment improved contractility but rapidly induced calcium-dependent pro-apoptotic signaling and cardiomyocyte apoptosis.
Stamm et al. (2002) studied this question.
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