Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2013Heart

A significant reduction in cardiovascular mortality, all-cause mortality, stroke, and heart failure was found with antihypertensive treatment versus non-drug placebo, with mean SBP difference linearly associated with risk reduction.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does antihypertensive treatment reduce cardiovascular mortality, all-cause mortality, stroke, and heart failure in hypertensive patients over 65 years of age?

Population

114,854 hypertensive patients over 65 years of age from 18 prospective randomized trials. Mean age of…

Comparison

Antihypertensive treatment (various regimens) vs Non-drug control group or alternative…

Design

Meta-analysis, prospective randomized trials

Follow-up

average 3.44 years

Authors

ΑBΑlexandros BriasoulisVAVikram AgarwalDTDimitris Tousoulis

Discussion

Loading...

Member takes

Overview

Supports antihypertensive treatment in hypertensives over 65; confirms linear SBP-driven reductions in mortality, stroke, and HF.

Structured PICO

Does antihypertensive treatment reduce cardiovascular mortality, all-cause mortality, stroke, and heart failure in hypertensive patients over 65 years of age?

P
Population
114,854 hypertensive patients over 65 years of age (55,569 on treatment, 59,285 controls) from 18 prospective randomized trials. Mean age of patients on treatment was 71.04 years.
I
Intervention
Antihypertensive treatment (various regimens)
C
Comparator
Non-drug control group (placebo) or alternative antihypertensive regimens
O
Outcome
Cardiovascular mortality, all-cause mortality, stroke, and heart failurehard clinical

Antihypertensive treatment in patients over 65 years of age significantly reduces the risk of stroke, heart failure, and mortality, with the benefit primarily driven by systolic blood pressure reduction.

Cite This Study

Briasoulis et al. (2013) studied this question.

synapsesocial.com/papers/6a7a66b14c448619ca0e244chttps://doi.org/10.1136/heartjnl-2013-304111
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension1991 · 2,963 citations
  2. 2Morbidity and mortality in the Systolic Hypertension in the Elderly Program (SHEP) pilot study.1989 · 130 citations
  3. 3Blood pressure reduction in elderly: a randomised controlled trial of methyldopa.1981 · 91 citations
  4. 4Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure: An Evaluation of Their Joint Effect on Mortality2003 · 214 citations
  5. 5Pharmacotherapy for hypertension in the elderly2009 · 219 citations