Key result
Antihypertensive therapy in patients ≥80 years old did not reduce total mortality (RR 1.06; 95% CI 0.89-1.25), but reduced the risk of stroke by 35% and heart failure by 50%.
Why the study?
Does antihypertensive therapy reduce total mortality in hypertensive patients 80 years and older?
Population
Hypertensive patients 80 years and older
Comparison
Antihypertensive therapy (active treatment) vs Placebo or no treatment
Design
Meta-analysis
Authors
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Supports BP lowering in octogenarians to cut stroke and HF risks; extends evidence by showing no mortality benefit.
Meta-Analysis
Does antihypertensive therapy reduce total mortality in hypertensive patients 80 years and older?
Effect estimate: RR 1.06 (95% CI 0.89-1.25)
In hypertensive patients aged 80 and older, antihypertensive therapy reduces stroke and heart failure but does not significantly affect total mortality.
Bejan‐Angoulvant et al. (2010) conducted a meta-analysis in Hypertension. Antihypertensive therapy vs. Placebo or no treatment was evaluated on Total mortality (RR 1.06, 95% CI 0.89-1.25). Antihypertensive therapy in patients ≥80 years old did not reduce total mortality (RR 1.06; 95% CI 0.89-1.25), but reduced the risk of stroke by 35% and heart failure by 50%.
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