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March 11, 2003BloodOpen Access

Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs

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Population

Cytokine-dependent cell line BaF3

Comparison

Deletion or truncation of specific cytoplasmic… vs Wild-type Mpl (implied)

Design

Preclinical

Authors

DDDebra D. DahlenVBVirginia C. BroudyJDJonathan G. Drachman

Discussion

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Overview

Identifies Mpl motifs essential for TPO-driven proliferation; leaves open translation to human thrombopoiesis or targeted therapies.

Structured PICO

P
Population
Cytokine-dependent cell line BaF3
I
Intervention
Deletion or truncation of specific cytoplasmic motifs of the thrombopoietin receptor (Mpl), specifically the fourth cytoplasmic tyrosine residue and residues 54-69
C
Comparator
Wild-type Mpl (implied)
O
Outcome
Receptor internalizationsurrogate

Two distinct motifs within the cytoplasmic domain of Mpl regulate ligand-dependent internalization, which appears essential for normal signal transduction and cellular proliferation.

Cite This Study

Dahlen et al. (2003) studied this question.

synapsesocial.com/papers/6a7a6ceca51ded8e7b32b8bfhttps://doi.org/10.1182/blood-2002-11-3468
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells1998 · 102 citations
  2. 2Di-leucine-mediated Internalization of Ligand by a Truncated Growth Hormone Receptor Is Independent of the Ubiquitin Conjugation System1998 · 47 citations
  3. 3Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling?1998 · 160 citations
  4. 4A Leucine-based Determinant in the Epidermal Growth Factor Receptor Juxtamembrane Domain Is Required for the Efficient Transport of Ligand-Receptor Complexes to Lysosomes1999 · 81 citations