What question did this study set out to answer?

To evaluate the pharmacokinetic behavior, oral bioavailability, and diuretic effects of furosemide in patients with severe congestive heart failure.

May 29, 2008Pharmacology

Pharmacokinetics of Furosemide in Patients with Congestive Heart Failure

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Authors

AGA. Goerz GreitherCalifornia Pacific Medical Center SGSteven GoldmanHeart Failure & Transplant JEJohn S. EdelenAlta Bates Summit Medical Center

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Implication

Pharmacokinetic evaluation reveals variable oral bioavailability and delayed absorption of furosemide in congestive heart failure, highlighting unpredictable drug responses.

Key Points

To evaluate the pharmacokinetic behavior, oral bioavailability, and diuretic effects of furosemide in patients with severe congestive heart failure.
Assessed oral and intravenous furosemide pharmacokinetics in N=7 patients with severe congestive heart failure.
Calculated bioavailability via oral to intravenous plasma concentration-time curve ratios and measured urinary flow rates over 24 hours.
Oral bioavailability averaged 61% with high interindividual variability (range: 34% to 80%) and an average absorption lag time of 28 ± 15 min.
Volume of distribution averaged 114 ml/kg, with clearance and elimination half-lives remaining consistent with values in healthy subjects.
Urinary flow rates at 1–2 h post-dose were significantly lower with oral versus intravenous dosing, though total urinary output was similar across both routes at 4, 8, and 24 h.

Cite This Study

Greither et al. (2008) studied this question.

synapsesocial.com/papers/6a7a737d2eb3c7e469f3fef8 https://doi.org/10.1159/000137299

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Implication

Pharmacokinetic evaluation reveals variable oral bioavailability and delayed absorption of furosemide in congestive heart failure, highlighting unpredictable drug responses.

Pharmacokinetics of Furosemide in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacokinetics of Furosemide in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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