What question did this study set out to answer?

To determine the elimination kinetics, clearance rates, and metabolic pathways of furosemide in healthy individuals compared to patients with kidney disease.

July 1, 1977Clinical Pharmacology & Therapeutics

Elimination of furosemide in healthy subjects and in those with renal failure

View Full Paper

Ask AI

Bookmark

To determine the elimination kinetics, clearance rates, and metabolic pathways of furosemide in healthy individuals compared to patients with kidney disease.
Administered intravenous furosemide to 5 healthy volunteers and 15 patients with varying degrees of renal failure, with 2 additional patients receiving oral doses.
Measured plasma half-life, plasma clearance, renal clearance, nonrenal clearance, and apparent volume of distribution relative to creatinine clearance.
Administered sulfur-35-labeled furosemide intravenously to one renal failure patient to trace metabolite clearance and excretion routes.
Plasma half-life averaged 0.79 hours in healthy subjects and increased up to 24.58 hours in patients with renal failure, though some severe cases maintained a near-normal half-life.
Plasma clearance (mean 194 ml/min in healthy controls) and renal clearance (mean 95 ml/min in healthy controls) decreased proportionally with declining creatinine clearance, while volume of distribution and nonrenal clearance showed no correlation.
In the patient evaluated with radiolabeled drug, metabolite elimination was substantially reduced, and fecal excretion replaced urinary excretion as the primary elimination pathway.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Pharmacokinetic study reveals reduced furosemide clearance and prolonged half-life in renal failure, highlighting altered drug elimination pathways.

Cite This Study

Beermann et al. (1977) studied this question.

synapsesocial.com/papers/6a7245ed26a7f98052de365c https://doi.org/10.1002/cpt197722170

View Full Paper

Ask AI

Bookmark

Implication

Pharmacokinetic study reveals reduced furosemide clearance and prolonged half-life in renal failure, highlighting altered drug elimination pathways.

Elimination of furosemide in healthy subjects and in those with renal failure

Key Points

Discussion

Implication

Cite This Study

Elimination of furosemide in healthy subjects and in those with renal failure

Key Points

Discussion

Implication

Cite This Study

Keep reading

Keep reading