Why the study?
Does adenovirus-mediated gene transfer of human lipoprotein lipase reduce plasma lipids in apoE-deficient, LDLr-deficient, and wild-type mice?
Does adenovirus-mediated gene transfer of human lipoprotein lipase reduce plasma lipids in apoE-deficient, LDLr-deficient, and wild-type mice?
Adenovirus-mediated LPL gene transfer effectively reduces total cholesterol and triglycerides in genetic mouse models of hyperlipidemia, suggesting a potential gene therapy approach for dyslipoproteinemias.
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Hypothesis-generating for LPL gene therapy in hyperlipidemia; leaves open human translation and safety trials.
Zsigmond et al. (1997) studied this question.
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