Why the study?
Does the prostaglandin I2 receptor suppress pressure overload-induced cardiac hypertrophy in mice?
Population
Female mice subjected to pressure overload-induced cardiac hypertrophy produced by banding of the transverse…
Comparison
Genetic deletion of the prostaglandin I2… vs Wild-type mice
Design
Preclinical
Follow-up
up to 8 weeks
Authors
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IP receptor deletion worsens pressure overload remodeling in mice; leaves open whether PGI2 agonism could mitigate human cardiac hypertrophy or fibrosis.
Does the prostaglandin I2 receptor suppress pressure overload-induced cardiac hypertrophy in mice?
The prostaglandin I2 receptor plays a suppressive role in the development of pressure overload-induced cardiac hypertrophy and fibrosis, likely acting on noncardiomyocytes.
Hara et al. (2005) studied this question.
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