Why the study?
Does the effect of spironolactone on potassium homeostasis vary between African-American and Caucasian patients with heart failure?
Population
117 patients with heart failure receiving a stable dosage of spironolactone in addition to standard heart…
Comparison
African-American race vs Caucasian race
Design
Cohort
Authors
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May warrant closer K+ monitoring in African-American HF patients on spironolactone; hypothesis-generating for race-specific effects.
Does the effect of spironolactone on potassium homeostasis vary between African-American and Caucasian patients with heart failure?
African-American patients with heart failure on spironolactone and ACEi/ARB therapy have lower serum potassium levels and require more potassium supplementation compared to Caucasian patients.
Cavallari et al. (2004) studied this question.
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