November 1, 1997American Journal of Respiratory and Critical Care Medicine
A Prospective Study of Patients with Lung Cancer and Hyponatremia of Malignancy
Population
50 patients with lung cancer, including 11 who presented with hyponatremia.
Design
Cohort
Authors
Discussion
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Member takes
Implication
AVP strongly associates with hyponatremia in lung cancer; leaves open whether AVP or ANP modulation improves sodium handling or outcomes.
Structured PICO
P
Population
50 patients with lung cancer (31 with small cell lung cancer and 19 with non-small cell lung cancer), including 11 who presented with hyponatremia.
I
Intervention
Saline infusion of 500 ml
O
Outcome
Impact of arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) on sodium homeostasis, assessed via serum and urine electrolytes, osmolality, and plasma hormones (AVP, ANP, PRA, angiotensin II, aldosterone) measured every 15 min before, during, and after saline infusion.surrogate
In patients with lung cancer, hyponatremia is strongly associated with elevated AVP, while ANP levels correlate with the physiological ability to excrete a sodium load.
Cite This Study
Johnson et al. (1997) studied this question.