January 24, 2000Physiological Genomics

Inflammation influences vascular remodeling through AT2receptor expression and signaling

View Full Paper

Ask AI

Bookmark

Why the study?

Does AT2 receptor expression influence vascular remodeling and smooth muscle cell proliferation after inflammatory injury in mice?

Population

Wild-type (Agtr2+) and AT2 receptor knockout (Agtr2-) mice

Comparison

Polyethylene cuff placement on the femoral artery vs Comparison between Agtr2+ and Agtr2- mice

Design

Preclinical

Authors

MAMasahiro AkishitaTokyo Metropolitan Institute of Gerontology MHMasatsugu HoriuchiGeneral Cardiology HYHiroyuki YamadaKeio University

Discussion

Member takes

Implication

AT2 receptor may limit post-injury vascular remodeling in mice; leaves open translation to human disease.

Structured PICO

Does AT2 receptor expression influence vascular remodeling and smooth muscle cell proliferation after inflammatory injury in mice?

Population

Wild-type (Agtr2+) and AT2 receptor knockout (Agtr2-) mice

Intervention

Polyethylene cuff placement on the femoral artery (model of vascular remodeling)

Comparator

Comparison between Agtr2+ and Agtr2- mice

Outcome

Neointimal lesion size and smooth muscle cell proliferationsurrogate

The AT2 receptor plays an important role in nonocclusive inflammatory injury by mediating the effects of inflammation on vascular smooth muscle growth inhibition.

Cite This Study

Akishita et al. (2000) studied this question.

synapsesocial.com/papers/6a7a8e83a51ded8e7b32c8bd https://doi.org/10.1152/physiolgenomics.2000.2.1.13

View Full Paper

Ask AI

Bookmark

Inflammation influences vascular remodeling through AT2receptor expression and signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inflammation influences vascular remodeling through AT2receptor expression and signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider