Why the study?
Does doxycycline reduce cardiac mechanical dysfunction, matrix metalloproteinase activity, and troponin I degradation after reperfusion in patients with coronary artery disease undergoing primary elective coronary artery bypass graft surgery with cardiopulmonary bypass?
Does doxycycline reduce cardiac mechanical dysfunction, matrix metalloproteinase activity, and troponin I degradation after reperfusion in patients with coronary artery disease undergoing primary elective coronary artery bypass graft surgery with cardiopulmonary bypass?
Perioperative low-dose doxycycline reduces cardiac MMP-2 activity but does not improve myocardial stunning in patients undergoing CABG with cardiopulmonary bypass.
Answers are grounded in this paper and cite their sources.
Doxycycline does not ameliorate post-CABG myocardial dysfunction; challenges MMP-2 inhibition as a strategy to mitigate reperfusion injury.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Schulze et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: