Why the study?
Does cystatin C based evaluation improve the detection of early renal impairment compared to creatinine in hypertensive patients?
Does cystatin C based evaluation improve the detection of early renal impairment compared to creatinine in hypertensive patients?
Serum cystatin C may be a more sensitive marker than serum creatinine for detecting early renal impairment in hypertensive patients.
Cystatin C may flag early renal impairment in treated hypertensive blacks better than creatinine; leaves open need for validation trials.
Background: Hypertension is a recognized cause of chronic kidney disease. Hypertension in blacks is most important because it is volume dependent and its ensuing renal complication. The widely accepted marker to assess renal function is creatinine and its estimated glomerular filtration rate. However, this is limited in assessing early renal impairment. This necessitate a need to evaluate other renal markers such as cystatin C. Objective: To measure and compare serum cystatin C and creatinine for early renal impairment among hypertensive patients on treatment. Methodology: A total of 48 hypertensive patients attending cardiology clinic for follow up were recruited in this study. Serum specimen were collected and assayed for creatinine and cystatin C. estimated glomerular filtration (eGFR) rate was calculated for the analytes. The two eGFR were compared in assessing renal function.
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K et al. (2016) studied this question.
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