Key result
Urea, uric acid, blood pressure, and BMI were significantly higher (p<0.05) in hypertensive subjects compared with healthy controls, whereas creatinine and cystatin C showed no significant difference.
Why the study?
Hypertension may cause progressive organ damage resulting in increased morbidity and mortality, warranting evaluation of renal markers.
Does hypertension increase the levels of selected renal markers (urea, creatinine, uric acid, cystatin C) in adults aged 18-50 years?
Cross-Sectional (n=92)
No
Does hypertension increase the levels of selected renal markers (urea, creatinine, uric acid, cystatin C) in adults aged 18-50 years?
Hypertension is associated with significantly elevated levels of urea and uric acid, suggesting these markers could help identify patients at risk for renal complications.
Answers are grounded in this paper and cite their sources.
Hypertension was associated with higher urea and uric acid; leaves open marker utility for renal risk and requires prospective validation.
Hypertension has become a serious health challenge in the 21 st century because it may cause organ damage as it progresses and could result in increased morbidity and mortality. The study evaluated selected renal markers (urea, creatinine, uric acid and cystatin C) in hypertensive subjects relative to control. A total of 92 subjects were investigated consisting of 31 hypertensive subjects on treatment, 31 hypertensives not on treatment and 30 apparently healthy subjects who served as control subjects. The levels of urea, creatinine and uric acid were determined using spectrophotometric methods while cystatin C was analyzed using enzyme linked immunoassay (ELISA) technique. Blood pressure and body mass index (BMI) were also measured in addition to the selected markers. The results showed that urea, uric acid, blood pressure and BMI were significantly higher at p<0.05 while creatinine and cystatin C did not show significant difference (p>0.05) in hypertensive subjects compared with control. It was concluded that urea, uric acid, blood pressure and BMI were significantly high in hypertension. Measurement of these markers could be helpful in identification of patients at high risk of developing renal complications associated with hypertension.
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A.O. Oluboyo (2020) conducted a cross-sectional in Hypertension (n=92). Hypertension vs. Healthy controls was evaluated on Levels of urea, uric acid, blood pressure and BMI (p=<0.05). Urea, uric acid, blood pressure, and BMI were significantly higher (p<0.05) in hypertensive subjects compared with healthy controls, whereas creatinine and cystatin C showed no significant difference.
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