Why the study?
Does bilateral electrolytic lesion of the anterior hypothalamus alter systemic and regional haemodynamics in normotensive and hypertensive rats?
Does bilateral electrolytic lesion of the anterior hypothalamus alter systemic and regional haemodynamics in normotensive and hypertensive rats?
Ablation of the anterior hypothalamus in rats produces a haemodynamic pattern resembling fighting and exercise, characterized by increased blood pressure, heart rate, and cardiac output, regardless of baseline blood pressure status.
Rat lesion effects do not inform practice; leaves open hypothalamic role in human hypertension.
Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior hypothalamus. 2. Anterior hypothalamic lesions produced an increase in blood pressure, heart rate and cardiac output. 3. In the rats with lesions there were changes in regional haemodynamics: heart and skeletal muscle flow increased; renal, skin ans splanchnic flow decreased. 4. The haemodynamic consequences of ablation of the anterior hypothalamus were similar in both normotensive Wistar-Kyoto and spontaneously hypertensive rats. The haemodynamic pattern resembles that seen during fighting and exercise.
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Suárez et al. (1980) studied this question.
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