What question did this study set out to answer?

To determine whether collateral blood vessels between the vertebrobasilar and carotid circulations explain why infant gerbils resist cerebral infarction following bilateral carotid occlusion.

September 1, 1983Journal of Cerebral Blood Flow & MetabolismOpen Access

Why are Infant Gerbils More Resistant Than Adults to Cerebral Infarction after Carotid Ligation?

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To determine whether collateral blood vessels between the vertebrobasilar and carotid circulations explain why infant gerbils resist cerebral infarction following bilateral carotid occlusion.
Nineteen Mongolian gerbils were categorized into three age groups: infants (3–4 weeks), young (5–7 weeks), and adults (10–17 weeks).
Bilateral common carotid artery occlusion was performed, followed by carbon black injection directly into the left ventricle via cardiac puncture to evaluate cerebral perfusion.
Whole-brain perfusion occurred in 5 of 8 infant gerbils, while the remaining 3 showed staining restricted to the cerebellum and brainstem with marked cerebral pallor.
Carbon black failed to perfuse carotid-supplied brain areas in all 11 young and adult gerbils across both older cohorts.

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Implication

Animal experiment reveals developed collateral cerebral blood flow in infant gerbils, explaining resistance to stroke after carotid ligation.

Cite This Study

Matsuyama et al. (1983) studied this question.

synapsesocial.com/papers/6a7aa868684c0941cf324bbf https://doi.org/10.1038/jcbfm.1983.55

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Implication

Animal experiment reveals developed collateral cerebral blood flow in infant gerbils, explaining resistance to stroke after carotid ligation.

Why are Infant Gerbils More Resistant Than Adults to Cerebral Infarction after Carotid Ligation?

Key Points

Discussion

Implication

Cite This Study

Why are Infant Gerbils More Resistant Than Adults to Cerebral Infarction after Carotid Ligation?

Key Points

Discussion

Implication

Cite This Study

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