Answers are grounded in this paper and cite their sources.
Demonstrates that dexamethasone reduces cerebral edema and mortality following unilateral carotid artery ligation in gerbils, suggesting protection against ischemic injury.
The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck in 60% of the cases studied. This mortality was reduced by large intraperitoneal injections of dexamethasone. Evidence is presented that this reduction in mortality is associated with a significant reduction in cerebral edema in the infarcted hemisphere.
No takes yet. Share an insight, caveat, or question.
Harrison et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: