Why the study?
Does prothrombin complex concentrate alter the relationship between INR and global coagulation tests in adult patients with warfarin-related intracranial bleeding?
Population
8 adult patients with intracranial bleeding related to anticoagulation with warfarin, mean age 72.
Design
Cohort
Follow-up
24 hours
Authors
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Post-PCC INR may underestimate reversal in warfarin ICH; leaves open whether thrombin generation or TEG better guides therapy.
Does prothrombin complex concentrate alter the relationship between INR and global coagulation tests in adult patients with warfarin-related intracranial bleeding?
In patients with warfarin-related intracranial bleeding, PCC corrects global coagulation parameters but INR does not fully correct and loses its correlation with actual thrombin generation.
Voils et al. (2015) studied this question.
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