What question did this study set out to answer?

To determine whether retinal deprivation at birth induces crossmodal alterations in auditory cortex activity and subplate neuron circuitry during the precritical developmental period.

February 21, 2023Open Access

Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

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Authors

DMDidhiti MukherjeeJohns Hopkins University BXBinghan XueNational Center for Advancing Translational Sciences CCChih-Ting ChenJohns Hopkins University

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Implication

Experimental study reveals early visual loss shifts auditory subplate circuits toward excitation in neonatal mice, indicating crossmodal plasticity emerges before the classic critical period.

Key Points

To determine whether retinal deprivation at birth induces crossmodal alterations in auditory cortex activity and subplate neuron circuitry during the precritical developmental period.
Deprived newborn mice of visual input at birth via bilateral enucleation.
Conducted in vivo imaging of the auditory cortex in awake neonatal pups during the first two postnatal weeks to monitor spontaneous and sound-evoked activity.
Performed whole-cell patch-clamp recordings paired with laser scanning photostimulation in auditory cortex brain slices to evaluate subplate neuron synaptic circuits.
Bilateral enucleation altered spontaneous and sound-evoked neural activity in the auditory cortex across the first two postnatal weeks in an age-dependent manner.
Visual deprivation altered intracortical inhibitory circuits impinging on subplate neurons, shifting the excitation-inhibition balance toward greater excitation.
The functional circuit shift toward heightened excitation persisted in subplate neurons after natural ear opening.

Cite This Study

Mukherjee et al. (2023) studied this question.

synapsesocial.com/papers/6a7aaa1714b028facf0e7cb1 https://doi.org/10.1101/2023.02.21.529453

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Implication

Experimental study reveals early visual loss shifts auditory subplate circuits toward excitation in neonatal mice, indicating crossmodal plasticity emerges before the classic critical period.

Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

Discussion

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Implication

Key Points

Cite This Study

Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

Discussion

Member takes

Implication

Key Points

Cite This Study

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