December 1, 1994Drug Development Research

New 1,4‐benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action

View Full Paper

Ask AI

Bookmark

Population

Experimental myofibrillar overcontraction model of isolated rat heart, isolated vascular smooth muscle of…

Comparison

K201 (a new 1,4-benzothiazepine derivative) vs Nicorandil, prazosin, propranolol, verapamil…

Design

Preclinical

Authors

NKNoboru KanekoNiigata University Medical and Dental Hospital

Discussion

Member takes

Implication

K201 merits further preclinical testing; leaves open clinical translation of its effects.

Structured PICO

Population

Experimental myofibrillar overcontraction model of isolated rat heart, isolated vascular smooth muscle of rat aorta, and cardiac annexin V with actin

Intervention

K201 (a new 1,4-benzothiazepine derivative)

Comparator

Nicorandil, prazosin, propranolol, verapamil, diltiazem, and KT362

Outcome

Degree of myofibrillar overcontraction histologically scored as myocardial injury score (MIS)surrogate

K201 is a novel 1,4-benzothiazepine derivative that demonstrates cardioprotective effects against myofibrillar overcontraction via intracellular calcium blocking action.

Cite This Study

Noboru Kaneko (1994) studied this question.

synapsesocial.com/papers/6a7aae26756812e39589b76e https://doi.org/10.1002/ddr.430330406

View Full Paper

Ask AI

Bookmark

New 1,4‐benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

New 1,4‐benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider