Why the study?
Does obesity-metabolic derangement exacerbate cardiomyocyte loss distal to moderate coronary artery stenosis in a porcine model?
Population
24 obesity-prone pigs (n=6 per group: lean-sham, ObM-sham, lean-CAS, and ObM-CAS)
Comparison
Atherogenic diet for 12 weeks to induce… vs Standard diet with or without CAS, and ObM…
Design
Preclinical, Randomized to four groups
Follow-up
4 weeks post-CAS induction (16 weeks total)
Authors
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Impaired autophagy may mediate obesity-exacerbated injury in stenotic myocardium; leaves open translation to human coronary disease.
Does obesity-metabolic derangement exacerbate cardiomyocyte loss distal to moderate coronary artery stenosis in a porcine model?
Obesity and metabolic derangements exacerbate myocardial injury and cardiomyocyte loss distal to moderate coronary stenosis in pigs, driven by impaired autophagy and increased apoptosis.
Li et al. (2014) studied this question.
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