Key result
Atherogenic diet for 14 weeks induced metabolic syndrome in pigs (n=6), which was associated with decreased myocardial autophagy and increased apoptosis compared to standard chow.
Why the study?
Does an atherogenic diet inducing metabolic syndrome alter myocardial autophagy and apoptosis in MetS-prone Ossabaw pigs?
Population
MetS-prone Ossabaw pigs (n=18)
Comparison
Atherogenic diet for 10 weeks or 14 weeks vs Standard chow for 10 weeks (lean group)
Design
Preclinical, randomized
Follow-up
10 to 14 weeks
Authors
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Highlights autophagy as potential target in metabolic syndrome; hypothesis-generating in this pig model and requires human validation.
RCT (n=18)
randomized
Does an atherogenic diet inducing metabolic syndrome alter myocardial autophagy and apoptosis in MetS-prone Ossabaw pigs?
The transition from obesity to metabolic syndrome is characterized by impaired myocardial cellular turnover, including decreased autophagy and increased apoptosis, highlighting a potential therapeutic target for preserving cardiac function.
Li et al. (2012) conducted an RCT in Obesity and Metabolic Syndrome (n=18). Atherogenic diet vs. Standard chow was evaluated on Cardiac structure, function, myocardial oxygenation, microcirculation, and injury mechanisms. Atherogenic diet for 14 weeks induced metabolic syndrome in pigs (n=6), which was associated with decreased myocardial autophagy and increased apoptosis compared to standard chow.
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