Why the study?
Does fundoplication prevent or reverse lung allograft dysfunction and bronchiolitis obliterans syndrome in lung transplant recipients with gastroesophageal reflux disease?
Does fundoplication prevent or reverse lung allograft dysfunction and bronchiolitis obliterans syndrome in lung transplant recipients with gastroesophageal reflux disease?
Chronic aspiration from GERD is an important nonalloimmune injury in lung transplant recipients that may initiate or exacerbate lung allograft dysfunction, and early fundoplication may prevent or reverse these sequelae.
Authors
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Early fundoplication may mitigate GERD-related allograft injury; hypothesis-generating and requires randomized trials before practice change.
Appel et al. (2005) studied this question.
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