May 1, 1988Clinical Cardiology
Rate‐responsive pacing with a pacemaker that detects respiratory rate (Biorate): Clinical advantages and complications
Why the study?
Does rate-modulated pacing with a respiratory-dependent pacemaker improve exercise capacity compared to constant rate ventricular pacing in patients with bradycardia?
Population
9 patients with bradycardia, mean age 58 (range 42-69) years.
Comparison
Rate-modulated pacing using a… vs Constant rate ventricular pacing.
Design
Case_series
Authors
Discussion
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Implication
May enhance exercise capacity in bradycardia; hypothesis-generating case report that should not change practice.
Structured PICO
Does rate-modulated pacing with a respiratory-dependent pacemaker improve exercise capacity compared to constant rate ventricular pacing in patients with bradycardia?
P
Population
9 patients with bradycardia, mean age 58 (range 42-69) years.
I
Intervention
Rate-modulated pacing using a respiratory-dependent pacemaker (RDP3 or MB-1, Biorate) that detects respiratory rate via thoracic impedance using a subcutaneous auxiliary lead.
C
Comparator
Constant rate ventricular pacing.
O
Outcome
Pacing rate and exercise capacity during symptom-limited treadmill exercise.surrogate
While a respiratory-dependent pacemaker improves exercise capacity compared to constant rate pacing, early iterations were limited by significant complications including auxiliary lead perforation and myopotential interference.
Cite This Study
Lau et al. (1988) studied this question.