Why the study?
What is the absolute bioavailability of eprosartan and the effect of food on its pharmacokinetics in healthy males?
Population
18 healthy males
Comparison
Single 300 mg oral dose of eprosartan and a… vs Fasting conditions vs high-fat breakfast for…
Design
Other
Authors
Loading...
Supports meal-independent dosing in healthy males; leaves open translation to patients.
What is the absolute bioavailability of eprosartan and the effect of food on its pharmacokinetics in healthy males?
Eprosartan has low oral bioavailability (13.1%) and its overall exposure is not clinically significantly altered by food, allowing administration without regard to meals.
Tenero et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: