Why the study?
Does age or gender affect the pharmacokinetics of a single 200 mg oral dose of eprosartan?
Population
24 subjects including young men, elderly men, and young, premenopausal women.
Comparison
Single 200 mg eprosartan oral dose vs Comparisons between groups
Design
Other
Follow-up
24 h
Authors
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No initial dose adjustment required in elderly despite higher exposure; extends eprosartan PK data across age and sex.
Does age or gender affect the pharmacokinetics of a single 200 mg oral dose of eprosartan?
Eprosartan exposure is approximately 2-fold higher in elderly men compared to young men, but no gender differences exist, and no initial dose adjustment is required for elderly patients.
Tenero et al. (1998) studied this question.
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