The rostro-caudal position of cardiac myocytes affect their fate

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Population

Chick embryos (stages 3-10)

Comparison

Cutting and rotating anterior lateral plate… vs Normal development / unrotated orientation

Design

Preclinical

Authors

Discussion

Positional cues specify atrial vs ventricular fate in chick precursors; leaves open relevance to mammalian cardiogenesis or congenital defects.

Population

Chick embryos (stages 3-10)

Intervention

Cutting and rotating anterior lateral plate mesoderm and underlying endoderm 180 degrees along the longitudinal axis at stages 4-8

Comparator

Normal development / unrotated orientation

Outcome

Diversification of precursor cells into atrial and ventricular myocytes assessed using lineage-specific markers

The rostro-caudal position of cardiac myocyte precursors during early chick embryogenesis determines their fate into atrial or ventricular myocytes.

Patwardhan et al. (2000) studied this question.

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Positional cues specify atrial vs ventricular fate in chick precursors; leaves open relevance to mammalian cardiogenesis or congenital defects.