Why the study?
Chronic kidney disease prevalence increases with comorbid liver diseases, prompting this assessment of the relationship between non-alcoholic fatty liver disease and CKD incidence in diabetic and non-diabetic subjects.
Does Non-alcoholic fatty liver disease (NAFLD) increase the incidence of chronic kidney disease in diabetic and non-diabetic subjects?
Population
1,111,046 diabetic and non-diabetic subjects across 19 studies
Comparison
NAFLD vs non-NAFLD
Design
Systematic review and meta-analysis
Authors
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NAFLD patients may need closer CKD monitoring regardless of diabetes; supports association but leaves open need for prospective trials.
Does Non-alcoholic fatty liver disease (NAFLD) increase the incidence of chronic kidney disease in diabetic and non-diabetic subjects?
NAFLD is associated with a nearly two-fold increased risk of incident chronic kidney disease, with diabetes acting as an independent and additive risk factor.
Chen et al. (2022) studied this question.
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