January 1, 1984The Journal of Biochemistry

Protein S Is Essential for the Activated Protein C-Catalyzed Inactivation of Platelet-Associated Factor Va1

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Population

In vitro model using thrombin-stimulated Factor V-deficient platelets and normal human platelets

Comparison

Protein S and activated protein C vs Absence of Protein S or use of thrombin-modified…

Design

Preclinical

Authors

KSKoji SuzukiSuzuka University of Medical Science JNJunji NishiokaSuzuka University of Medical Science MMMichio MatsudaNihon University

Discussion

Member takes

Implication

Animal data support Protein S cofactor role in coagulation; leaves open human therapeutic translation.

Structured PICO

Population

In vitro model using thrombin-stimulated Factor V-deficient platelets and normal human platelets

Intervention

Protein S and activated protein C

Comparator

Absence of Protein S or use of thrombin-modified protein S

Outcome

Rate of inactivation of platelet-associated Factor Vasurrogate

Protein S is essential for the efficient inactivation of platelet-associated Factor Va by activated protein C, highlighting its critical role in regulating coagulation.

Cite This Study

Suzuki et al. (1984) studied this question.

synapsesocial.com/papers/6a7ac3372eb3c7e469f420c2 https://doi.org/10.1093/oxfordjournals.jbchem.a134857

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Protein S Is Essential for the Activated Protein C-Catalyzed Inactivation of Platelet-Associated Factor Va1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protein S Is Essential for the Activated Protein C-Catalyzed Inactivation of Platelet-Associated Factor Va1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider