Key result
Activated protein C inhibits thrombin-activated bovine platelet prothrombin-converting activity in a time-dependent manner, causing a parallel loss of factor Xa receptor sites.
Why the study?
Does activated protein C inhibit platelet prothrombin-converting activity in thrombin-activated bovine platelets?
Population
Bovine platelets activated by thrombin
Design
Preclinical
Authors
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May inform coagulation models in animals; leaves open translation to human thrombosis.
Does activated protein C inhibit platelet prothrombin-converting activity in thrombin-activated bovine platelets?
Activated protein C inhibits platelet prothrombin-converting activity and reduces factor Xa receptor sites, suggesting a role in the regulation of clotting.
Comp et al. (1979) studied this question. Activated protein C was evaluated on Platelet prothrombin-converting activity. Activated protein C inhibits thrombin-activated bovine platelet prothrombin-converting activity in a time-dependent manner, causing a parallel loss of factor Xa receptor sites.
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