Activated protein C inhibits thrombin-activated bovine platelet prothrombin-converting activity in a time-dependent manner, causing a parallel loss of factor Xa receptor sites.
Does activated protein C inhibit platelet prothrombin-converting activity in thrombin-activated bovine platelets?
Activated protein C inhibits platelet prothrombin-converting activity and reduces factor Xa receptor sites, suggesting a role in the regulation of clotting.
Bovine platelets that have been activated by thrombin facilitate the conversion of prothrombin to thrombin in the presence of calcium ions and factor Xa. Activated protein C, a vitamin-K-dependent plasma protein, inhibits this platelet prothrombin-converting activity. The inhibition is time dependent and is not reversed by increasing concentrations of factor Xa. However, factor Xa is able to protect the platelet prothrombin-converting activity from inactivation by activated protein C. The activated protein C causes a parallel loss of factor Xa receptor sites and platelet prothrombin-converting activity. Activated protein C may contribute to the regulation of clotting through inactivation of the platelet prothrombin-converting activity.
Comp et al. (Sat,) reported a other. Activated protein C was evaluated on Platelet prothrombin-converting activity. Activated protein C inhibits thrombin-activated bovine platelet prothrombin-converting activity in a time-dependent manner, causing a parallel loss of factor Xa receptor sites.
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