Why the study?
Does CABG and optimal medical therapy reduce all-cause mortality compared to medical therapy alone in patients with ischemic heart failure and diabetes mellitus?
Population
1212 patients with an LVEF of ≤35% and CAD amenable to coronary artery bypass grafting, with and without…
Comparison
Coronary artery bypass grafting and optimal… vs Optimal medical therapy (MED) alone
Design
RCT, Randomized to CABG and optimal medical therapy (MED) or MED alone
Authors
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DM status does not modify CABG benefit in ischemic HF; leaves open whether targeted trials can refine revascularization decisions.
Does CABG and optimal medical therapy reduce all-cause mortality compared to medical therapy alone in patients with ischemic heart failure and diabetes mellitus?
In patients with ischemic heart failure and reduced ejection fraction, CABG did not exert a greater mortality benefit in patients with diabetes mellitus compared to those without diabetes.
MacDonald et al. (2015) studied this question.
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