May 11, 1979JAMA
Diabetes and cardiovascular disease. The Framingham study
Why the study?
Does diabetes increase the risk of cardiovascular events in the Framingham cohort?
Population
Framingham cohort
Comparison
Prior evidence of diabetes vs Nondiabetic
Design
Cohort
Follow-up
20 years
Authors
Discussion
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Member takes
Implication
Supports targeted surveillance for claudication and HF in diabetes; extends classic cohort data but leaves causal effects open.
Key Points
- To evaluate the long-term impact of diabetes on the incidence of subsequent cardiovascular disease manifestations and related mortality.
- Tracked cardiovascular events across 20 years of prospective surveillance within the Framingham cohort based on prior diabetes status.
- Assessed incidence of coronary heart disease, intermittent claudication, congestive heart failure, and stroke, adjusting for co-occurring cardiovascular risk factors.
- Diabetes was associated with a twofold to threefold increased risk of clinical atherosclerotic disease, with coronary heart disease representing the greatest absolute burden.
- The relative risk associated with diabetes was highest for intermittent claudication and congestive heart failure, with a substantially greater relative impact observed in women than in men.
- After adjustment for associated risk factors, relative risks for coronary heart disease, stroke, and intermittent claudication were similar between sexes, whereas relative risk of congestive heart failure and cardiovascular mortality remained higher in women.
Structured PICO
Does diabetes increase the risk of cardiovascular events in the Framingham cohort?
P
Population
Framingham cohort
I
Intervention
Prior evidence of diabetes
C
Comparator
Nondiabetic
O
Outcome
Subsequent cardiovascular events (clinical atherosclerotic disease)hard clinical
Diabetes confers a 2- to 3-fold increased risk of clinical atherosclerotic disease, with a particularly pronounced relative impact on cardiovascular mortality and heart failure in women.
Cite This Study
William B. Kannel (1979) studied this question.