Why the study?
Advancing age is the major risk factor for chronic diseases and increases healthcare burden, suggesting that targeting shared disease mechanisms across age-related diseases may be more productive than tackling each disease individually.
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Design
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Shifting focus to shared aging mechanisms may reduce multiple chronic disease burdens; leaves open which interventions warrant trials.
Advancing age is the major risk factor for chronic diseases, such as cardiovascular disease, type 2 diabetes, cancer and Alzheimer's disease. The rising number of older individuals is thus resulting in an increased burden on our healthcare system. Instead of tackling each of these age-related diseases one by one, focused approaches aimed at the identification of shared disease mechanisms, that can ideally be targeted using lifestyle and/or pharmacological interventions, could be more productive.
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Joris Deelen (2021) studied this question.
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