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June 3, 2026Signal Transduction and Targeted TherapyOpen Access

Insights into the therapeutic strategies for aging and aging-associated diseases

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Authors

RDRuifang DongNational University of SingaporeQWQiming WuInstitute of AgingJKJuntao KanAmway (United States)

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Implication

Review summarizes advancements in interventions targeting aging mechanisms for improved healthspan.

Key Points

  • This review aims to explore therapeutic strategies that target the biological processes of aging and associated diseases.
  • Summarizes current breakthroughs in aging therapeutics.
  • Identifies three main strategies: senolytics, senomorphics, and metabolic interventions.
  • Discusses the role of artificial intelligence in accelerating discovery in aging research.
  • Senolytics demonstrated effectiveness in eliminating senescent cells, enhancing lifespan in preclinical models.
  • Metabolic interventions improved mitochondrial function, activated autophagy, and demonstrated lifespan-extension effects.
  • The integration of AI facilitated the identification of new compounds and biomarkers for personalized aging therapies.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc44edee9eb8c0dce5dbchttps://doi.org/10.1038/s41392-026-02662-z
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