Why the study?
Do catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes?
Do catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes?
Catecholamines potentiate LPS-induced MMP expression in human monocytes via beta-receptors, providing a potential mechanism for peri-operative plaque instability and supporting the use of peri-operative beta-blockade.
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Animal data suggest beta-receptor MMP potentiation; leaves open translation to human perioperative plaque instability.
Speidl et al. (2004) studied this question.
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