The effect of atrial natriuretic peptide on human isolated resistance arteries
Why the study?
Does (1-28) alpha-human atrial natriuretic peptide (ANP) relax human isolated resistance arteries?
Population
Human isolated resistance arteries taken from tissue removed at surgery
Design
Preclinical
Authors
Discussion
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Member takes
Implication
ANP's heterogeneous effects on human resistance arteries warrant caution in assuming uniform vasodilation; hypothesis-generating for site-specific vascular regulation.
Structured PICO
Does (1-28) alpha-human atrial natriuretic peptide (ANP) relax human isolated resistance arteries?
P
Population
Human isolated resistance arteries (renal, skeletal muscle, omental and subcutaneous) taken from tissue removed at surgery
I
Intervention
(1-28) alpha-human atrial natriuretic peptide (ANP) (10(-9)-10(-6) M)
O
Outcome
Isometric tension responses (relaxation of precontracted segments)surrogate
The vasodilatory effect of ANP on human resistance arteries is heterogeneous and depends on the anatomical site of origin, affecting renal and skeletal muscle arteries but not omental or subcutaneous arteries.
Cite This Study
Hughes et al. (1989) studied this question.