Why the study?
Do changes in central venous pressure induced by passive leg raising and whole-body tilting alter plasma hANP levels in normal subjects?
Population
Normal volunteers (n=10 for passive leg raising, n=9 for head up whole-body tilt)
Comparison
Passive leg raising to 60 degrees for 20 min… vs Baseline (supine/recumbency position)
Design
Other
Follow-up
20 minutes
Authors
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Postural CVP changes may modulate hANP secretion in normals; leaves open relevance to volume disorders or therapeutic targeting.
Do changes in central venous pressure induced by passive leg raising and whole-body tilting alter plasma hANP levels in normal subjects?
Changes in posture that alter central venous pressure physiologically regulate the secretion of human atrial natriuretic polypeptide.
Ogihara et al. (1986) studied this question.
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