Key result
Shifting from recumbent to upright posture is linked to a ~48% decrease in plasma ANP.
Why the study?
Postural factors influence plasma atrial natriuretic polypeptide levels and must be accounted for to properly evaluate ANP, PRC, and PAC under physiological conditions.
Do sequential changes in posture affect plasma atrial natriuretic polypeptide concentrations in healthy human subjects?
Population
Healthy human subjects
Comparison
Sequential changes in posture vs recumbent posture
Design
Observational study using radioimmunoassay
Authors
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Posture must be standardized for ANP sampling; leaves open its diagnostic role in volume disorders or HF.
Observational
Do sequential changes in posture affect plasma atrial natriuretic polypeptide concentrations in healthy human subjects?
Plasma ANP levels are significantly suppressed by upright posture, indicating that postural factors must be controlled when evaluating these biomarkers.
Sakurai et al. (1987) conducted an observational in Healthy. Sequential changes in posture (recumbency, sitting, upright) vs. Continuous recumbent posture was evaluated on Plasma immunoreactive atrial natriuretic polypeptide (ANP) levels. Sequential changes in posture from recumbency to upright positions suppressed plasma atrial natriuretic polypeptide levels from 150 pg/ml to 78.1 pg/ml in healthy subjects.
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