December 1, 1987The Journal of Clinical Endocrinology & Metabolism
Effect of Posture on Clearance of Atrial Natriuretic Peptide from Plasma*
Why the study?
Does body posture affect the clearance of atrial natriuretic peptide from plasma in normal men?
Population
8 normal men
Comparison
Posture change during constant IV infusion of… vs Supine posture (baseline and recovery)
Design
Other
Authors
Discussion
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Implication
Posture may warrant control in ANP sampling protocols; leaves open effects on diagnostic thresholds in disease.
Structured PICO
Does body posture affect the clearance of atrial natriuretic peptide from plasma in normal men?
P
Population
8 normal men
I
Intervention
Posture change (supine to erect to supine) during constant IV infusion of alpha-Human ANP at 0.5 micrograms/min (162 pmol/min)
C
Comparator
Supine posture (baseline and recovery)
O
Outcome
Plasma ANP levels and calculated metabolic clearance rate (MCR) of ANPsurrogate
Body posture significantly affects the rate of clearance of atrial natriuretic peptide from plasma, with clearance decreasing upon standing.
Cite This Study
Gillies et al. (1987) studied this question.